Systematic ReviewIF 24.1
Statin intolerance vs. nocebo: an updated Bayesian network meta-analysis
n = 81 RCTs · 213,902 participants
Vol 14 · Issue 5May 2026Continuously updated
Medical intelligence,
engineered for evidence.
TICH is a peer-reviewed scientific publishing platform, a live public-health surveillance hub, and an AI clinical assistant — built for clinicians, regulators, and researchers across Africa and the world.
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Global Health Signal
Refreshed 2 min ago · 1,284 sources
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Influenza A
↑ 4.2%
RSV
↓ 1.1%
H5N1
↑ 0.8%
TICH AI brief
14 sourcesWastewater H5N1 signals are rising in 4 East-African sites. Clinical impact remains low; review the surveillance brief and updated FAQ.
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01 · Featured Clinical Intelligence
What clinicians are reading this week
Breaking developments, emerging therapies, and clinical alerts — selected by the editorial board.
Editor's pick
Peer-reviewed
GRADE: High
Clinical Medicine · 11 min · DOI 10.55102/tich.2026.0512
GLP-1 receptor agonists and cardiometabolic outcomes: a 2026 living meta-analysis
Pooled data from 47 RCTs (n=312,540) show consistent reductions in MACE, with new safety signals on gastroparesis and bone density.
AO
Dr. Amara Okonkwo, MD PhD
Reviewed by Prof. Lin Wei, FRCP · May 14, 2026
Trending
Epidemiology · 9m
Wastewater surveillance for H5N1: signal-to-action lag across 38 cities
Reviewed May 09, 2026
Open Access
Pharmacy · 13m
Pharmacist-led antimicrobial stewardship in LMIC tertiary hospitals
Reviewed May 03, 2026
Nutrition · 8m
Ultra-processed foods and midlife cognitive trajectories
Reviewed Apr 28, 2026
02 · Research Spotlight
Systematic reviews, trials & meta-analyses
Highest-impact, citable evidence — with reproducibility data and open peer review.
RCT · Phase 3Pre-registered
Once-weekly tirzepatide in HFpEF: primary endpoint NEJM-class result
n = 2,418 · 28 sites
Meta-AnalysisGRADE: High
Maternal RSV vaccination and infant hospitalization across 14 cohorts
n = 412,008 mother–infant dyads
Pragmatic TrialOpen Data
Pharmacist-led AMR stewardship in 41 LMIC tertiary hospitals
23% ↓ carbapenem use · NS mortality
Cohort · 11yReplication ✔
Ultra-processed foods and midlife executive function decline
UK Biobank linked · n = 188,470
Diagnostic AccuracyOpen Code
Foundation-model triage in EDs: a multi-site stepped-wedge
AUROC 0.91 · bias audit included
03 · Public Health Intelligence
Live epidemiology dashboards
Outbreak maps, vaccination coverage, AMR monitoring, and pharmacovigilance — updated every 15 minutes from 1,284 verified sources.
Global outbreak atlas
94 countries · 38 active signals
Active outbreaks
38
Under monitoring
112
Contained (30d)
27
Vaccination coverage
Measles (MCV1)84%
DTP379%
HPV (girls 9–14)41%
RSV (maternal)47%
AMR sentinel
Carbapenem-R Enterobacterales
↑ 6.4%
MRSA bloodstream
→ 0.2%
ESBL E. coli (UTI)
↑ 3.1%
Multi-drug TB
↓ 1.8%
04 · Pharmaceutical Regulatory Center
Rwanda FDA · WHO · ICH — synthesized for clinicians
Drug recalls, safety alerts, pharmacovigilance signals, and ADR reporting in one place.
RECALLRwanda FDA
Losartan 50mg — voluntary recall of batches LT-2426 and LT-2431
NDEA impurity above ICH M7 limit · 14 May 2026
SAFETY ALERTWHO Uppsala Monitoring
SGLT2 inhibitors: updated DKA reporting guidance
Signal strength: moderate · 12 May 2026
APPROVALEMA · CHMP
First-in-class oral GLP-1/GIP for HFpEF — positive opinion
Conditional · post-authorization studies required
PV SIGNALTICH Pharmacovigilance
Increased gastroparesis reports with semaglutide ≥ 1.7 mg
n = 1,284 reports · IC025 = 1.42
GUIDELINEICH E6(R3)
Good Clinical Practice — revised principles in force
Operative date: 01 Jul 2026
RECALLFDA (US)
Pediatric paracetamol oral suspension — labeling error
Lot-specific · supply-chain advisory
05 · AI Health Tools
Clinical-grade AI, grounded in TICH's library
Every output is traceable to peer-reviewed sources. Never diagnostic — always cited.
TICH AI Medical Assistant
Citation-first answers across TICH's 12,408 peer-reviewed sources.
Open tool
Drug Interaction Checker
Real-time DDI screening with severity grading and references.
Open tool
Clinical Risk Calculators
ASCVD, FRAX, qSOFA, CHA₂DS₂-VASc, MELD-Na and more.
Open tool
Literature Review AI
Synthesize hundreds of papers into structured evidence summaries.
Open tool
06 · Clinical Categories
Browse by specialty
Curated topic clusters with the latest evidence, guidelines, and clinical pearls.
07 · Clinical Learning Hub
Guidelines, pathways & CME
From bedside protocols to accredited continuing medical education.
CME Modules
62 accredited modules · self-paced
Clinical Guidelines
WHO · NICE · ESC · ACC · IDSA
Diagnostic Pathways
Step-by-step decision trees
Case Discussions
Weekly grand-round transcripts
08 · Digital Health Media
Podcasts, video & infographics
Evidence translated for clinicians, students, and the public.
PODCAST · S3 E14
What we learned from 47 GLP-1 RA trials
42 min · with Prof. Lin Wei
VIDEO
How wastewater surveillance actually works
8 min · animated explainer
INFOGRAPHIC
Pediatric antibiotic stewardship at a glance
Downloadable · CC BY 4.0
09 · Journal Ecosystem
Open-access. DOI-registered. Reproducible.
The TICH Journal publishes peer-reviewed research with ORCID-linked authors, named reviewers, and open data.
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380 reviewers · 41 specialties · 6 continents — operating under COPE, ICMJE, and GRADE methodology.
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